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Conference
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) |
| Jan 13-18, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the |
Mechanotransduction in Physiology and Disease (A7) |
| Jan 18-23, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; |
Emerging Tumor Suppressors (B1) |
| Jan 25-30, 2009 at Sagebrush Inn and Conference Center , Taos New Mexico United States |
| This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakersxe2x80x99 laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. |
B Cells in Context (C3) |
| Feb 24-Mar 1, 2009 at Taos Convention Center , Taos New Mexico United States |
| B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools |
Genome Instability and DNA Repair (C6) |
| Mar 1-6, 2009 at Taos Convention Center , Taos New Mexico United States |
| DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented. |
